Nanotechnology features An array of possibilities to contribute to biology. Listed here I will current examples the place nanofabrication – the opportunity to make confined buildings with Proportions at will – is applied to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
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2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is often a very flexible protein framework; and very first detection of DNA knots utilizing nanopores
The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased overall flexibility
Given that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with micro organism on chip, although his greatest desire is within the way of noticing synthetic cells.
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Understanding fundamental processes regulating the spatial and dynamic organisation of the DNA in live cells.
Dekker started his investigate on solitary carbon nanotubes in 1993 when he put in place a fresh line of research to check electrical transport as a result of solitary organic molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was achieved in a very collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography approaches had been utilized to exhibit that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.
[14] In 2005 Dekker grew to become involved in Netherlands-extensive discussions about Smart Structure, a movement that he has considering the fact that Obviously distanced himself from. Dekker advocates that science and faith aren't in opposition but is often harmonized.
Nanoscientist Cees Dekker is undoubtedly an amiable and flamboyant gentleman who appears much young in comparison to the sixty two several years he actually is – modern Eyeglasses, psychedelic shirt, engaging smile – although not just one to waste time. He requires his time, but not more than important.
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It absolutely was a really appealing time, during which I acquired loads of assistance from Delft University of Know-how, where I was a professor at enough time, And that i begun a number of collaborations with molecular biologists. That aided me study a lot.’